Single cell atlas of the human retina - Amacrine cell subclass

Main

Cell Metadata

HAC1

Ontology Term: amacrine cellCL:0000561
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: AC, amacrine neuron, ACs
Category Class of which the cell type is a subclass.: retinal cellCL:0009004
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: IGF2BP2
Canonical Marker Genes: unknown
Rationale: 100.0%Gly7 of the Sanes dataset; 99.4%Gl7 of the macaque dataset; 99.7%AC33 of the mouse dataset;Known markers are curated from human, macaque and mouse markers.

Set of Labels Description: Over 73 amacrine cell types were identified among over 380K amacine nuclei in the current atlas. These 73 cell types can be categorized into GABAergic amacine cells, Glycinergic amacine cells, and Both type using marker genes, specifically the GABA-synthetic enzymes GAD1 and GAD2, and the glycine transporter SLC6A9. Based on previously characterized markers, 14 of the 73 amacrine cell clusters cound be annotated as known amacrine types.
Annotation Method: manual

Ontology Term: amacrine cellCL:0000561
Synonyms Terms that have the same, or nearly the same, meaning as the selected cell type.: AC, amacrine neuron, ACs
Category Class of which the cell type is a subclass.: retinal cellCL:0009004
Ontology Assessment Disagreements with any aspect of the Cell Ontology.: —
Marker Gene Evidence Gene markers used by researcher to assign this cell annotation.: IGF2BP2
Canonical Marker Genes: unknown
Rationale: 100.0%Gly7 of the Sanes dataset; 99.4%Gl7 of the macaque dataset; 99.7%AC33 of the mouse dataset;Known markers are curated from human, macaque and mouse markers.

Set of Labels Description: Over 73 amacrine cell types were identified among over 380K amacine nuclei in the current atlas. These 73 cell types can be categorized into GABAergic amacine cells, Glycinergic amacine cells, and Both type using marker genes, specifically the GABA-synthetic enzymes GAD1 and GAD2, and the glycine transporter SLC6A9. Based on previously characterized markers, 14 of the 73 amacrine cell clusters cound be annotated as known amacrine types.
Annotation Method: manual