Single cell atlas of the human retina - Retinal ganglion cell subclass

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I fully agree with the annotation for MG_OFF. The marker expression and morphological characteristics are consistent with microglial off-state cells, supporting the current classification.

I agree

test

• MG_ON_A:
  • CRNDE
• MG_ON_B:
  • EBF2
• MG_ON_C:
  • KANK4

I disagree with the current annotation for MG_ON. The gene expression profiles suggest heterogeneity within the cluster, and I believe it should be split into three distinct subclusters for more accurate characterization.

• Group 1:
  • SOX2
• Group 2:
  • SLIT3

My short explanation...

I completely disagree with the annotation for HRGC3. The gene expression profile does not align with this label, suggesting this cluster represents a different cell type entirely and requires re-evaluation

Not enough information

I tend to Agree

Looks good to me.

I suggest merging the HRGC4, HRGC13, and HRGC14 clusters. These cells exhibit highly similar gene expression patterns, indicating they likely represent the same cell population and should be combined for a more cohesive analysis.

I don't know anything about HRGC5 and can't judge its annotation. I would need more information or context to provide meaningful feedback.

Hmmm....

These cell labels could be the same!

Approved

My short explanation...

I would agree

My short explanation...

These cell labels could be the same!

I suggest merging the HRGC4, HRGC13, and HRGC14 clusters. These cells exhibit highly similar gene expression patterns, indicating they likely represent the same cell population and should be combined for a more cohesive analysis.

I suggest merging the HRGC4, HRGC13, and HRGC14 clusters. These cells exhibit highly similar gene expression patterns, indicating they likely represent the same cell population and should be combined for a more cohesive analysis.

Can't say something precise

Don't know