Single cell atlas of the human trabecular meshwork and ciliary body - scRNA-seq
Summary
This atlas is an integrated collection of over 332K cells, derived from single-cell RNA-seq data of the human trabecular meshwork and ciliary body. These cells have been categorized into 9 major classes and 19 sub-classes.
Metadata
Dataset Type
Single. The file includes a single dataset whereby “dataset” means a single library or a set of technical replicates that can be combined without having to worry about the associated batch effect.
This cell annotation set focuses on the trabecular meshwork (TM) and ciliary body (CB), key tissues regulating aqueous humor dynamics and intraocular pressure in the human eye. Using single-cell RNA-seq, we analyzed over 332K cells from 36 healthy donors, identifying 9 major cell classes and 19 sub-classes. As part of the Human Cell Atlas initiative, this dataset integrates transcriptomic and chromatin accessibility data and is publicly accessible via CELLxGENE and the UCSC Cell Browser, offering a valuable resource for understanding ocular physiology and disease mechanisms.
