Human liver cell atlas - hepatocyte cells

Main

Cell Metadata

Summary

The main parenchymal liver cells responsible for metabolism, detoxification, and protein synthesis. These are version 1 cell type labels and may be subject to change.

Metadata

Dataset Type: Single. The file includes a single dataset whereby “dataset” means a single library or a set of technical replicates that can be combined without having to worry about the associated batch effect.
Total Cells: 228,368
organism: Homo sapiens
disease: normal
assay: 10x 3' v3 (118,100 cells)10x 3' v2 (74,599 cells)10x 5' v1 (35,669 cells)
tissue: caudate lobe of liver (141,620 cells)liver (86,607 cells)left lobe of liver (108 cells)right lobe of liver (33 cells)

Cell Labels

Summary

The main parenchymal liver cells responsible for metabolism, detoxification, and protein synthesis. These are version 1 cell type labels and may be subject to change.

Metadata

Dataset Type: Single. The file includes a single dataset whereby “dataset” means a single library or a set of technical replicates that can be combined without having to worry about the associated batch effect.
Total Cells: 228,368
organism: Homo sapiens
disease: normal
assay: 10x 3' v3 (118,100 cells)10x 3' v2 (74,599 cells)10x 5' v1 (35,669 cells)
tissue: caudate lobe of liver (141,620 cells)liver (86,607 cells)left lobe of liver (108 cells)right lobe of liver (33 cells)

Cell Labels

author_cell_type

Description

HLiCA classifies cells into six lineages and 48 distinct cell types, 18 more than previous studies. Rigorous benchmarking ensured robust integration across technical and biological variables. Expanded annotations allowed identification of previously undetected liver cell types. As the largest human liver cell atlas, HLiCA serves as a genetically diverse, well-annotated reference.

Annotation Method

both